/ɒnˈdænsɛtrɒn/; developed and first marketed by GlaxoSmithKline as Zofran) is a serotonin 5-HT3receptor antagonist used mainly as an antiemetic (to treatnausea and vomiting), often following chemotherapy. It affects both peripheral and central nerves[1].
Ondansetron reduces the activity of the vagus nerve, which deactivates the vomiting center in the medulla oblongata, and also blocks serotonin receptors in the chemoreceptor trigger zone.
It has little effect on vomiting caused by motion sickness, and does not have any effect on dopamine receptors or muscarinic receptors.
It is also used off-label to treat hyperemesis gravidarum in pregnant women, but there is no conclusive data available on its safety inpregnancy, especially during the first trimester.
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